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Cell-surface receptors, usage

Laboratory-adapted R5 strains and primary isolates of HIV-1 differ in their co-receptor usage and the ability to infect monocytes and macrophages. Laboratory-adapted R5 strains of HIV-1 can infect freshly isolated monocytes (adult and neonatal sources) at earlier stages of maturation than primary isolates, as they can utilize lower levels of both CD4 and CCR5 than primary isolates. Neonatal monocytes are less permissive to infection with primary HIV-1 isolates than adult cells, and their susceptibility to infection correlates with maturation and increasing surface expression of CCRS. ... [Pg.87]

See other pages where Cell-surface receptors, usage is mentioned: [Pg.356]    [Pg.265]    [Pg.268]    [Pg.472]    [Pg.483]    [Pg.549]    [Pg.1]    [Pg.238]    [Pg.684]    [Pg.366]    [Pg.366]    [Pg.249]   
See also in sourсe #XX -- [ Pg.226 ]



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