Cell-surface elastin receptor

The process of elastic fiber assembly " is mediated by a non-integrin cell surface complex, named the cell-surface elastin receptor (CSER), which can be captured... 

A. Hinek, T. D. Bodnaruk, S. Bunda, Y. Wang, and K. Liu, Neuraminidase-1, a subunit of the cell surface elastin receptor, desiafylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF-2, Am. J. Pathol, 173 (2008) 1042-1056. 

The true nature of this molecule has been hard to identify unequivocally, however. Recent experiments with antibodies to the 68 kDa laminin receptor have shown that it may be used as a positional marker for dorsal embryonic retina, in a variety of vertebrates (Rabacchi et al., 1990). Similar work by McCaffery et al. (1990) has shown that the dorso-ventral asymmetry of this protein has 4 peculiarities in immunoblots the molecular mass of the receptor is not 68 kDa, but 43 kDa the molecular mass of the protein deduced from cDNA is only 33 kDa (see also Auth and Brawerman, 1992) the antibodies stain a cytoplasmic antigen, not a cell surface protein and, despite the pronounced dorso-ventral difference seen after immunostaining, the 43 kDa protein identified by immunoblotting appears evenly distributed throughout the retina. The authors concluded from sequence homology that the molecule may constitute a translation-initiation factor that reflects asymmetries in some aspect of protein translation. Attempts to further characterize this receptor have been both controversial and difficult, although it is possible that it shares identity with a molecule identified as a joint elastin/laminin receptor (Martin and Timpl, 1987). 

Several surface-bound receptors on cells, including EBP, have been studied to evaluate cell-matrix interactions, especially with elastin-derived matrices. Several studies have described the role of EBP elastin-binding interactions and downstream effects including cell proliferation, chemotaxis, and changes in cell morphology for several cell types including smooth muscle cells, endothelial cells, fibroblasts, and MSCs [101-104]. 

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