Cell stabilisers

Topical mast cell stabilisers are best used for prophylaxis of allergic eye symptoms. Sodium cromoglicate is effective in most people. Lodoxamide and nedocromil are more expensive, but may be worth trying in people with inadequate response to sodium cromoglicate. Mr JA cannot use eye drops because he wears contact lenses therefore nasal corticosteroids are recommended. 

Sodium cromoglicate is known as a mast cell stabiliser. Its mode of action is not entirely understood but it is thought to act by stabilising mast cell membranes and preventing their degranulation. It counteracts both the early and late response to allergen exposure. 

Sodium cromoglicate and lodoxamide are mast cell stabilisers. Both are used four times daily and are suitable for children. 

In addition to remnants of monomers and catalysts, PU foams may also have remnants of several other components used during their preparation as well, such as cell-stabilisers, blowing agents, flammability retarding agents and accelerators. 

Samiulla DS, Prashanth D, Amit A (2001) Mast cell stabilising activity of Bacopa monnieri. Fitoterapia 72 284-285... 

Gan Z., Ellis P. R., Schofield J. D. (1995). Mini review Gas cell stabilisation and gas retention in wheat bread dough. Journal Cereal Science, 21, pp. 215-230... 

The application of synthetic glycopolymers in signal transduction and protein/cell stabilisation has emerged as a relatively new area for such materials. The impact of glycopolymer structure on... 

Surface active agents are important components of foam formulations. They decrease the surface tension of the system and facilitate the dispersion of water in the hydrophobic resin. In addition they can aid nucleation, stabilise the foam and control cell structure. A wide range of such agents, both ionic and non-ionic, has been used at various times but the success of the one-shot process has been due in no small measure to the development of the water-soluble polyether siloxanes. These are either block or graft copolymers of a polydimethylsiloxane with a polyalkylene oxide (the latter usually an ethylene oxide-propylene oxide copolymer). Since these materials are susceptible to hydrolysis they should be used within a few days of mixing with water. 

Pericytes are mural cells which stabilise capillaries and control functions of capillary endothelial cell properties. 

TAK-1 can also activate c-jun N-terminal kinase ( JNK) andp38 both of which are MAP kinases. JNK activates the transcription factor AP-1 and p38 is involved in mRNA stabilisation. This pathway is also capable of activating ERF-7 in dendritic cells in response to TLR-7 and TLR-9 ligands. 

Czauderna E, Eechtner M, Dames S, Aygun H, Klippel A, Pronk GJ, Giese K, Kaufmann J (2003) Structural variations and stabilising modifications of synthetic siRNAs in mammahan cells. 

Surfactants used as lubricants are added to polymer resins to improve the flow characteristics of the plastic during processing they also stabilise the cells of polyurethane foams during the foaming process. Surfactants are either nonionic (e.g. fatty amides and alcohols), cationic, anionic (dominating class e.g. alkylbenzene sulfonates), zwitterionic, hetero-element or polymeric (e.g. EO-PO block copolymers). Fluorinated anionic surfactants or super surfactants enable a variety of surfaces normally regarded as difficult to wet. These include PE and PP any product required to wet the surface of these polymers will benefit from inclusion of fluorosurfactants. Surfactants are frequently multicomponent formulations, based on petro- or oleochemicals. 

---