Cell interferon interaction with

Interferons There are two types of interferons Type I, which includes IFN-a and IFN-jS, and Type II consisting of IFN-y. IFN-a and IFN- 8 have about 30% homology in amino acid sequence. There are two more recently discovered Type I interferons they are called IFN-o and IFN-t. IFN-a and IFN- 8 each have 166 amino acids, and IFN-yhas 143. Both IFN-a and IFN-jS are of single chain structure and bind to the same type of cell surface receptors, whereas IFN-y is a dimer of two identical chains and interacts with another type of receptor. All our cells can produce Type I interferons when infected by viruses, bacteria, and fungi. However, only T cells and natural killer cells can produce... 

Site of action The exact mechanism by which the interferons are cytotoxic is unknown, but they have the capacity to stimulate natural killer (NK) cells, y Interferon is also a potent activator of tumori-cidal macrophages. Interferon secreted from producing cells interacts with surface receptors on other cells, at which site they... 

Non-professional APCs do not constitutively express the MHC proteins required for interaction with naive T-cells these are expressed only upon stimulation of the non-professional APC by certain cytokines, such as IFN-y (interferon-gamma). Non-professional APCs include fibroblasts (skin), thymic epithelial cells, thyroid epithelial cells, ghal cells (brain), pancreatic... 

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