Acute generalized cefotaxime

Skin Acute generalized exanthematous pustulosis (AGEP) has been attributed to cefotaxime in a 30-year-old woman who received cefotaxime, fosfomydn, and ciprofloxacin for sinusitis for 12 days the symptoms resolved within 11 days after cefotaxime withdrawal. Patch tests were positive to cefotaxime after 48 hours and negative to ciprofloxacin and fosfomydn [10 ]. 

Skin Acute generalized exanthematous pustulosis has been attributed to cefotaxime after 12 days in a 30-year-old woman and confirmed by a positive patch test [61 ]. 

Chaabane A, Aouam K, Gassab L, Njim L, Boughattas NA. Acute generalized exanthematous pustulosis (AGEP) induced by cefotaxime. Fundam Clin Pharmacol 2010 24(4) 429-32. 

Penicillin-induced renal toxicity is most commonly seen as allergic acute interstitial nephritis (AIN). Methicillin is the most common penicillin to induce AIN, but the use of penicillin G, ampicillin, am-oxacillin, oxacillin, and carbenicillin also can lead to the development of AIN. Typically, acute renal failure follows 1 or 2 weeks of treatment with fever or rashes sometimes occurring before overt renal dysfunction. Removal of the penicillin generally allows renal function to return to normal within a few days or weeks. AIN can also be induced by certain cephalosporins (e.g., cephalothin, cephalexin, cephradine, cefoxitin, cefotaxime) and non-/i-lactam antimicrobials (e.g., sulfonamides, rifampicin, tetracyclines, erythromycin). 

---