Cefoperazone Ethanol

Metronidazole (also cefamandole, cefoperazone) Ethanol (drugs containing ethanol) Disulfiram-like reaction Avoid... 

The MTT group has also been implicated in the intolerance to alcohol a.ssociatcd with certain injectable cephalosporins ccfamandole, cefotcian. ccfmetazolc, and cefoperazone. Thus, disulfiram-like reactions, attributed to the accumulation of acetaldehyde and resulting from the inhibition of aldehyde dehydrogenase-catalyzed oxidation of ethanol by M lT-contuining cephalo.sporins. " may occur in patients who have consumed alcohol before, during, or shortly after the course of therapy. 

Cefotetan, cefoperazone and cefamandole cause hypoprothrombinemia and also disulfrram-like interactions with ethanol. 

Only a few cephalosporins (eg, cefoperazone, cefotetan, moxalactam) cause disulfiram-Uke reactions with ethanol. Sulfonylureas used in type 2 diabetes may cause such reactions, and ethanol may enhance their hypoglycemic actions, especially in fasting patients. The answer is (A). 

Cefoperazone Cefamandole Cefotetan Moxalactam Cefmetazole 102-156 min 30-50 min 3-4.6 h 114-150 min 72 min 3-4 mg/L One case of symptomatic hepatitis. All of these antibiotics have the /V-methyltetrazoletniol side chain which may inhibit aldehyde dehydrogenase to cause a disulfiramlike interaction with ethanol (see p 186) and coagulopathy (inhibition of vitamin K production). 

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