Ceanothus integerrimus

The four new cyclopeptide alkaloids (19a)—(19d) isolated from the shrub Ceanothus integerrimus contain a para-bridged fourteen-membered-ring nucleus (19), for which the name phencyclopeptine has been proposed.16 The crude alkaloidal extract from Ceanothus sanguineus17 showed the presence of five major components on composite field-desorption mass spectrometry. H.p.l.c., however, yielded six alkaloids, two of which were isomeric and one of which was a new alkaloid (20). The bark of Scutia buxifolia contains five scutianine alkaloids (B, C, D, E, and H) H is new, and is (21).18 Two new cyclopeptides, sativanines A and B, have been identified as (22) and (23) by m.s.-n.m.r. study.19... 

Sources Ceanothus integerrimus ax. //7tepe/r//77(/5(Rhamnaceae)-root bark 45)... 

Ceanothus integerrimus var. califomicus (rb), C. integerrimus var. integerrimus (rb) see Deoxo-aralionine-A (98)... 

Tschesche, R., J. Rheingans, H.-W. Fehlhaber, and G. Legler Integerressin und Integerrenin, zwei Peptid-Alkaloide aus Ceanothus integerrimus Hook, et Am. Chem. Ber., 100, 3924 (1967). 

Lagarias, J.C., D. Goff, F.K. Klein, and H. Rapoport Cyclopeptide Alkaloids. Phencyclopeptines from the Polymorphic Species Ceanothus integerrimus. J. Nat. Prod., 42, 220 (1979). 

Tschesche, R., E. Frohberg, and H.-W. Fehlhaber Alkaloide aus Rhamnaceen, IV. Integerrin, ein weiteres Peptid-Alkaloid aus Ceanothus integerrimus Hook et Am. Tetrahedron Lett., 11, 1311 (1968). 

Alkaloids have been found in the family and several species known to be positive were also identified in this study Alphitonia macrocarpa, Ceanothus americanus (2/2), C. integerrimus (1/2), Hovenia dulcis (1/3), Zizyphus jujuba (1/3), Z. maurilania (2/4), Z. mucronata (3/7), Z. oenoplia. 

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