CE coupled to mass spectrometry

The hyphenation of CE with techniques allowing structural determination of impurities is the object of Chapter 18 Coupling CE and Microchip-based Devices and Mass Spectrometry of this book, but the potential of CE coupled to mass spectrometry (CE/MS) in impurity profiling has also been discussed elsewhere. ... 

The analyses of egg proteins by CZE, CIEF, or MEKC were reviewed by Recio et al. In addition, an interesting application of CE coupled to mass spectrometry (CE-MS) was the detection of lysozyme from chicken and turkey egg white. Since one of the problems of protein separations was the possible interaction with the capillary wall, a polymer coating compatible with CE-MS was developed, and the usefulness of this method was shown by the analysis of a minced meat extract containing chicken egg white as adulterant (Table 30.8). ... 

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