Cdk inhibitors

Sherr CJ, Roberts JM (1999) CDK inhibitors positive and negative regulators of G1-phase progression. Genes Dev 13 1501-1512... 

Growth inhibition by TGF- 3, associated with inhibition of c-myc, cdks, reduction in cyclin D1 levels, and inhibition of cdk-4-associated Rb kinase activity, as well as induction of cdk inhibitors pi5 and p27, has been noted in intestinal epithelial cells. Loss of responsiveness to growth inhibition from TGF- 3 occurs in many cell types including breast, colorectal carcinoma, and pancreatic carcinoma cells. Mutational inactivation of T 3RH represents one mechanism of this process, which in many cases, leads to the development of gastrointestinal cancer. Thirteen percent of colorectal carcinomas are thought to be associated with a replication error (RER) or microsatellite instability phenotype. Subsequent inactivation of T 3RII and... 

Raff The phenot ype of the p27 knockout mice suggests such timers do play a part in size control. The simplest explanation for why you get more cells in these mice is that p27 normally plays a role in taking cells out of division at the right time. Cdk inhibitor mutations seem to play similar roles in flies and worms. p27 is clearly not the only component of the stopping mechanism. If you take it out of action, the cells still stop, just not at the right time. 

In 1998-99, she worked on the synthesis of cyclin-dependent kinase (CDK) inhibitors, under the direction of Professor Miguel F. Brana at University San Pablo (CEU, Spain). 

Feldman, R. M., et al., A complex of Cdc4p, Skplp, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Siclp. Cdl, 1997, 91, 221-30. 

Mamillapalli, R., et al., PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIPl) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol, 2001, 11(4), 263-7. 

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