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CDK2 inhibition

CDK2 is involved with controlling normal cell proliferation. Disregulation in cancer makes this a good antitumor target. Pevarello et al. [62] describe the parallel optimization of enzyme inhibition potency, cellular activity, physicochemical properties, and PK. A low MW hit (MW = 201) was specifically selected with the... [Pg.204]

Nahum, A., K. Hirsch, M. Danilenko et al. 2001. Lycopene inhibition of cell cycle progression in breast and endometrial cancer cells is associated with reduction in cyclin D levels and retention of p27(Kipl) in the cyclin E-cdk2 complexes. Oncogene 20(26) 3428-3436. [Pg.433]

See other pages where CDK2 inhibition is mentioned: [Pg.226] [Pg.238] [Pg.239] [Pg.243] [Pg.400] [Pg.165] [Pg.101] [Pg.332] [Pg.32] [Pg.226] [Pg.238] [Pg.239] [Pg.243] [Pg.400] [Pg.165] [Pg.101] [Pg.332] [Pg.32] [Pg.343] [Pg.343] [Pg.47] [Pg.50] [Pg.43] [Pg.49] [Pg.49] [Pg.49] [Pg.50] [Pg.66] [Pg.74] [Pg.228] [Pg.229] [Pg.445] [Pg.473] [Pg.432] [Pg.189] [Pg.171] [Pg.27] [Pg.210] [Pg.344] [Pg.20] [Pg.9] [Pg.77] [Pg.5] [Pg.51] [Pg.142] [Pg.143] [Pg.154] [Pg.215] [Pg.216] [Pg.217] [Pg.220] [Pg.222] [Pg.225] [Pg.225] [Pg.228]

See also in sourсe #XX -- [ Pg.254 , Pg.255 ]

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CDK2