Caudal regression syndrome

Caudal regression syndrome is a rare anomaly, a continuum of congenital malformations ranging from isolated sacral agenesis to absence of the lumbosacral spine and major visceral anomalies. While the exact canse of this syndrome is unclear, maternal diabetes, genetic factors, teratogens, and vascular anomalies that alter blood flow have been hypothesized to play a role. A case has been attributed to maternal minoxidil exposure (15). 

Nievelstein RAJ, Valk J, Smit LME et al (1994) MR of the caudal regression syndrome embryologic implications. AJNR 15 1021-1029... 

Fig. 5.30. Ureterohydronephrosis induced by fecaloma (patient with caudal regression syndrome and dysplastic kidneys)...

Duhamel B (1961) From the mermaid to anal imperforation the syndrome of caudal regression. Arch Dis Childhood 36 152-155... 

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