Cation serial combinatorial synthesis

Figure 4.46 Schematic of serial combinatorial synthesis for creating a cation pool from diverse carbamates and silyl enol ethers [66. ...

OS 30] [R 30] [P 22] By simple flow switching, serial combinatorial synthesis for creating a cation pool from diverse carbamates and silyl enol ethers was accomplished (Figure 4.46) [66, 67]. The conversions and selectivities were comparable to continuous processing using three feed streams only (see Conversion/yield/selec-tivity, above). 

Serial Combinatorial Synthesis Based on the Cation Flow Method... 

Figure 4.3 Serial combinatorial synthesis based on the cation flow method. (a) Schematic diagram (b) example based on the reaction of N-acyliminium ion pools with carbon nucleophiles...

Figure 7.6 Continuous serial combinatorial synthesis using the cation flow system.

Figure 9.7 Serial combinatorial synthesis based on the cation flow method.

As C-C bond formation is an important step in organic synthesis, particularly for pharmaceutical applications, it is useful to look for operation modes of chemical micro processing that allow one to carry out combinatorial chemistry investigations. As such, the serial introduction of multiple reactant streams by flow switching was identified [66,67]. The wide availability of precursors for acyiiminium cations has led to the expression cation pool [66, 67]. 

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