Catalyzed Coupling of Alkylamines

Tlie classic Ullmann reactions catalyzed by ligandless copper do not occur with aliphatic amines, but the coupling of aryl halides with aliphatic amines does occur in the presence of some ligated copper catalysts. Tlie scope of the coupling of aliphatic amines typically 

CHAPTER 19 TRANSITION METAL-CATALYZED COUPLING REACTIONS 

HN = primary alkylamines or cyclic secondary amines Amino acid = L-proline, A/-methyl glycine, or A/,A/-dimethylgycine 

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