Catalytic combinatorial libraries enantioselective

Sharpless et al. coined the word ligand-accelerated catalysis (LAC), which means the construction of an active chiral catalyst from an achiral precatalyst via ligand exchange with a chiral ligand. By contrast, a combinatorial library approach in which an achiral pre-catalyst combined with several chiral ligand components (L, L, —) may selectively assemble in the presence of several chiral activators (A, A, —) into the most catalytically active and enantioselective activated catalyst (ML A" ) (Scheme 8.16). ... 

Aires-de-Sousa, J. and Gasteiger, J. (2005) Prediction of enantiomeric excess in a combinatorial library of catalytic enantioselective reactions. /. Comb. Chem., 7, 298. 

Enantiomeric Excess in a Combinatorial Library of Catalytic Enantioselective Reactions. 

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