Catalyst template design

Hydroamination is also a valuable process since it incorporates a synthetic handle into a hydrocarbon fragment that can be used to template or promote further functionalization. Although this approach is remarkably popular, there are considerable issues with regiose-lectivity and stereoselectivity, and each set of substrates should be evaluated against the array of available catalysts when designing a synthesis. 

Third Concept in Catalyst Design. Fenton Detemplation. Mild Organic Template Removal in Micro- and Mesoporous Molecular Sieves... 

C. Hofstetter, P. S. Wilkinson, T. C. Pochapsky, NMR Structure Determination of Ion Pairs Derived from Quinine A Model for Templating in Asymmetric Phase-Transfer Reductions by BH4" with Implications for Rational Design of Phase-Transfer Catalysts , J. Org. Chem 1999, 64, 8794-8800. 

The strategy used to design active and selective catalysts was based on the following five factors for regulation, (i) conformation of ligands coordinated to Rh atom (ii) orientation of a vacant site on Rh (iii) cavity with the template molecular shape for reaction space produced behind template removal (iv) architecture of the cavity wall and (v) micropore in inorganic polymer-matrix overlayers stabilizing the active species at the surface [46, 47, 71]. 

Figure 4.12 Extrusion templates enable the design of catalyst pellets with different shapes and sizes.

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