Catalyst Structure and Cis-Trans Selectivity in Ruthenium-based Olefin Metathesis

Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA 

A wide variety of early-TM carbenes, particularly those of molybdenum and tungsten, were found to be efficient olefin metathesis catalysts and could be tuned for various applications through careful ligand selection [3b, 4], However, they typically were sensitive to air and water and had poor tolerance to particular functional groups, such as 

Ligand Design in Metal Chemistry Reactivity and Catalysis, First Edition. Edited by Mark Stradiotto and Rylan J. Lundgren. 

Initially, there were two limiting factors in the utility of metathesis selective formation of a desired olefinic product from the mixture of possible olefins and formation of that product as a single cis or trans stereoisomer. A model for olefin reactivity has allowed for selective formation of a single product in a number of cases 

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Catalyst Structure and Cis-Trans Selectivity in Ruthenium-based Olefin Metathesis... 

Catalyst Structure and Cis-Trans Selectivity in Ruthenium-based Olefin Metathesis 33 2.4 Z-selective Ru-based metathesis catalysts 2.4.1 Thiophenolate-based Z-selective catalysts... 

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