Casein-specific IgE

The ability of LAB diet enhanced IFN production to regulate the Thl/Th2 responses has been thoroughly studied in animal models. Feeding OVA-primed mice with L. casei has been shown to reduce antigen-specific IgE responses in vivo (Yasui et al. 1999). A murine model of food allergy has also demonstrated that intraperito-neal administration of L. plantarum can downregulate casein-specific IgE antibody levels in vivo and IL-4 secretion as well (Murosaki et al. 1998). 

Here, we showed that the production of casein-specific IgE Ab in mice immunized with casein/CFA was suppressed by oral administration of CVE, and that the production of casein-specific IgG2a levels was enhanced by oral administration of CVE, whereas the expressions of IL-12 and IFNy mRNAs were increased in the spleens of mice after immunization with casein/CFA. These results suggested that CVE may be useful as a therapeutic or prophylactic agent to control allergy accompanied by the elevation of allergen-specific IgE Abs. 

Nakajima-Adachi, H., Hachimura, S., Ise, W., Honma, K., Nishiwaki, S., Hirota, M. et al. 1998. Determinant analysis of IgE and IgG4 antibodies and T cells specific for bovine alpha(s)l-casein from the same patients allergic to cow s milk existence of alpha(s)l-casein-specific B cells and T cells characteristic in cow s-milk allergy. J Allergy Clin Immunol 101(5) 660—671. 

Bernard, H., Creminon, C., Yvon, M., and Wal, J.M. 1998. Specificity of the human IgE response to the different purified caseins in allergy to cow s milk proteins. Int Arch Allergy Immunol 115(3) 235—244. 

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