Phenobarbital Carmustine

CARMUSTINE ANTIEPILEPTICS -PHENOBARBITAL 1 plasma concentrations of carmustine and 1 anti-tumour effect in animal experiments Attributed to induction of liver metabolizing enzymes of carmustine by phenobarbitone, particularly with long-term therapy Avoid concurrent use. As this study did not show any interaction with phenytoin, phenytoin may be a suitable alternative antiepileptic... 

Phenytoin Phenobarbital Vinblastine Carmustine Methotrexate Lung cancer with brain metastases Phenytoin ieveis feii from 9.4 to 5.6 micrograms/mL 24 hours after vinblastine. Patient fitted. Phenytoin ieveis returned to normai 2 weeks after chemotherapy. Phenobarbitai ieveis unaffected. 4... 

Nine patients treated with carmustine 80 mg/m daily for 3 days, cimetidine 300 mg four times daily for 1 to 4 weeks, steroids, and cranial irradiation over 6 weeks, demonstrated marked leucopenia during the first cycle. Bone marrow aspirates confirmed the marked decrease in granulocytic elements in 2 patients. In comparison, 31 patients treated similarly, but without cimetidine, had no significant white cell depression. Neutropenia was found in a man taking regular cimetidine, phenytoin, phenobarbital, and dexamethasone, 53 days after he was given lomustine 120 mg, and 16 days after he was given lomustine 160 mg. The cimetidine was discontinued and the neutropenia rapidly reversed within 14 days. The neutrophil nadir from the lomustine 160 mg dose occurred after a further 16 to 19 days and was much less severe. ... 

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