Cardiovascular system xanthine effects

Fluvastatin (Fig. 21) is a member of the drug class of statins used to treat hypercholesterolemia and to prevent cardiovascular disease. It is able to decrease ROS, such as hydroxyl radicals and superoxide anions generated by the Fenton reaction, and by the xanthine-xanthine oxidase system. The an-tioxidative effect of fluvastatin was thought to have caused not only the scav-... 

Most stilbenoids possess antioxidant activities because they possess polyphenol functions in the molecules. Some of their beneficial effects, hepatoprotective action, cardiovascular protection, for instance, are in close relation to their antioxidant activities. Several models have been employed in the assay such as lipid peroxidation system, human low-density lipoprotein model, xanthine oxidase system and l,l-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging model, which is the most commonly used protocol. 

The introduction of an extra nitrogen into the xanthine system to give 8-azaxanthines had been reported to reduce cardiovascular effects ( ) and we found that 8-azatheophylline (III) was 10 times more active than the corresponding theophylline or 6-thiotheophylline in inhibiting the rat PCA reaction whereas the other pharmacological properties were reduced in magnitude. A series of 8-azaxanthines (IT) were prepared and the best of these compounds was found to be the p-nitrobenzyl derivative (V) which was equiactive witti DSG in the rat PCA test ( ),... 

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