Cardiovascular system vasorelaxation

Thyroid hormone has multiple effects on the cardiovascular system with various physiological consequences. Several genes that encode important regulatory and structural proteins in the heart have been shown to be thyroid hormone responsive. Thyroid hormone increases cardiac contractility, induces vasorelaxation and angiogenesis, prevents fibrosis and has favorable effects on lipid metabolism (reviewed by Pantos73). 

Oleuropein activity on NO production is very interesting and may resolve some pathological problems such as platelet aggregation, thrombosis, vasorelaxation, etc [76], In fact, NO exerts several effects on cardiovascular system, exhibits vasorelaxant activities and reacts with superoxide to form peroxynitrite (see Figure 26). 

Effects with the autonomous nervous system have also merited attention. Over the cardiovascular system anti arrhythmic 341), antieschemic (555), antihemorrhagic 348), antifibrillatory 346), PAF inhibition 435), vasorelaxant 449), and hypotensive activities (552) are some of the important biological effects reported for the protober-berine alkaloids in the period covered by this review. Also important to mention are the metabolic effects hypoglycemic 351,404), antihypercholesterolemic 350), bone resorption inhibition (5(56), osteoclast formation inhibition (566), lipase and lipogenesis inhibition 412,414), and prostaglandin synthesis inhibition 438), are a few of the reported activities related to metabolism. 

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