Cardiovascular modeling

Although other species have been tested, the dog is the species of choice for the mammalian cardiac sensitization model because the dog is a reliable cardiovascular model for humans, has a large heart size, and can be trained to calmly accept the experimental procedures (Aviado 1994 NRC 1996). The cardiac sensitization test was evaluated by NRC (1996) who recommended that the male beagle be used as the model in this test. 

The text by Rideout [1991] has a particularly good tutorial on cardiovascular modeling and even includes ACSL source code. McDonald s [1974] and Noordergraaf s [1978] texts are classics, thoroughly reviewing cardiovascular physiology and the physical principles useful in modehng it. More recent texts on the... 

The cardiovascular model shown in Figure 1 may be subdivided arbitrarily into cardiac and vascular components. Coupling between these components takes... 

These results suggest that CORM-3 is transported in circulation as a serum albumin or transferrin adduct that slowly decomposes to release CO without sudden bursts. This kind of mechanism is supported by the observation of steady, low levels of CO in the treatment of mice with CORM-3 in a cardiovascular model [83], One important consequence of this mechanism is that it lacks tissue specificity. Actually, CORM-3 is active in a broad variety of indications affecting different tissues and organs [62, 66]. Interestingly, the methylthiogalactose ligand was able to convey a reasonable liver specificity to complex ALF492 (Fig. 41.2), which became much more efficacious then CORM-3 in the protection of mice in a model of cerebral malaria [82]. 

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