Cardioprotection, beta-blocker

Carvediol is a vasodilator with beta-adrenergic antagonist activity. It has cardioprotective activity in animal models. The antioxidant effect of carvediol was compared with five other beta blockers in iron-initiated lipid peroxidation, where it inhibited TBARs formation and protected membrane-bound tocopherol in rat brain homogenate (Yue et al., 1992a). The ortJ <)-substituted phenoxylethyl-amine is responsible for the improved antioxidant activity. [Pg.270]

Y. Suematsu, V. Anttila, S. Takamoto and P.J. del Nido, Cardioprotection afforded by ischemic preconditioning interferes with chronic beta-blocker treatment, Scan. Cardiovasc. J. 38,293-299, (2004). [Pg.75]

The question arose whether these observed changes in cAMP, and by implication, beta-adrenergic activation, played any role in the cardioprotection of ischemic preconditioning. Using the beta-1 adrenergic blocker alprenolol 7.5 x 10 5M during... [Pg.70]

Hjalmarson A Cardioprotection with beta-adrenoceptor blockers Does lipophilicity matter Basic Res... [Pg.107]

Hjalmarson, A. (2(XX)) Cardioprotection with Beta-Adrenoceptor Blockers. Does Lipophihcity Matter Basic Res. Cardiol. 95 (Suppl. 1), 141-145. [Pg.220]

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