Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Cardiac Glycosides and Anticancer Activity

Saponins are extremely poisonous, as they cause heamolysis of blood and are known to cause cattle poisoning. Some saponins are important from therapeutic point of view, as in Digitalis pupurea, the presence of saponins is necessary for activity of cardiac glycosides. Recent studies have shown that saponins have hypolipdemic and anticancer activity. [Pg.132]

It is known that the inhibition of Na /K ATPase activates tyrosine kinase sarcoma (Src), phosphoinositide-3 kinase (PI3K), and phospholipase C signalosome complex, which can induce many antiproliferative downstream effects related to cell growth and apoptosis [1—3]. Since some anticancer effects of cardiac glycosides... [Pg.3746]

The proof of concept example examined the cardiac glycoside digitoxin (Scheme 3.15, 61). Digitoxin is an interesting target as it is a well-known inhibitor of the plasma membrane Na+/K" -ATPase (ATP, adenosine triphosphate), hut also is known to have anticancer activity, activity against polyglutamine disorders, and to... [Pg.86]

See other pages where Cardiac Glycosides and Anticancer Activity is mentioned: [Pg.3745]    [Pg.3747]    [Pg.3749]    [Pg.3751]    [Pg.3753]    [Pg.3756]    [Pg.3745]    [Pg.3747]    [Pg.3749]    [Pg.3751]    [Pg.3753]    [Pg.3756]    [Pg.47]    [Pg.877]    [Pg.687]    [Pg.741]    [Pg.1200]    [Pg.1216]    [Pg.57]    [Pg.694]    [Pg.740]    [Pg.999]    [Pg.59]    [Pg.94]    [Pg.20]    [Pg.1179]    [Pg.69]    [Pg.236]    [Pg.3744]    [Pg.236]   


SEARCH



Cardiac glycosides

Glycosides, and glycosidation

Glycosidic activation

© 2024 chempedia.info