Encapsulated papillary carcinoma

FIGURE 19.16 Another case of intracystic (encapsulated) papillary carcinoma demonstrating strong continuous collagen type IV staining. 

Encapsulated papillary carcinoma Absent within, rare +/- around ducts Similar to DCIS, unless frankly invasive... 

Esposito NN, Dabbs DJ, Bhargava R. Are encapsulated papillary carcinomas of the breast in situ or invasive A basement membrane smdy of 27 cases. Am J Clin Pathol. 2009 131 228-242. 

There is considerable controversy with respect to the presence of CK19 in hyalinizing trabecular tumors of the thyroid. Fonseca and coworkers reported CK19 in all cases of hyalinizing trabecular tumors and suggested that this tumor represented a peculiar encapsulated variant of papillary carcinoma. Hirokawa and colleagues, in contrast, found no or minimal CK19 in their series of cases. 

Sconamiglio T, Hyjek E, Kao J, et al. Diagnostic usefulness of HBME-1, galectin-3, CK19 and CITEDl and evaluation of their expression in encapsulated lesions with questionable featrrres of papillary thyroid carcinoma. Am J Clin Pathol. 2006 126 700-708. 

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