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Carcinogenicity studies transgenic mice

Carcinogenicity Tg.rasH2 transgenic mouse model Other antigenicity in guinea pigs, mice, and rats tumor cell lines (effects of the product on proliferation) human tumor xenografts in athymic nude mice hemolytic potential studies... [Pg.1062]

Historically, the regulatory requirements for the assessment of the carcinogenic potential of pharmaceuticals recommended the conduct of long-term carcinogenicity studies in two rodent species, usually the rat and the mouse. In the 1990s, the use of transgenic mice was introduced in an attempt to improve the process of hazard identification.24 Deficiencies of the conventional bioassay are well known and include the following 25-26... [Pg.12]

Several lines of evidence indicate that phase II enzymes such as NAD(P)H (quinone-acceptor) oxidoreductase (NQOl) and glutathione 5-transferase (GST) play a role in the cellular detoxification of genotoxic and carcinogenic chemicals. Recently, two transgenic rodent studies clearly demonstrated that Class n GST (GSTPl), one of the GST isozymes, can profoundly alter the susceptibility to chemical carcinogenesis in mouse skin (I) and rat liver (2). The Class n rat and human GST isozymes have been... [Pg.358]

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See also in sourсe #XX -- [ Pg.871 ]



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Mouse carcinogenicity studies

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