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Carcinogenicity metabolic aspects

Miller JA, Miller EC (1983) Some historical aspects of N-aryl carcinogens and their metabolic activation. Env Health Persp 49 3-12... [Pg.29]

Schoor, W.P. 1984. Benzo(a)pyrene metabolism in marine fish and some analytical aspects of its metabolites. Pages 391-396 in K.L. Hoover (ed.). Use of Small Fish in Carcinogenicity Testing. Natl. Cancer Inst. Mono. 65. Bethesda, MD. [Pg.1406]

It is not known how chemicals cause cancer. A fascinating aspect of the story is that many "carcinogenic" chemicals are in fact, not the culprits responsible for cancer induction. The metabolic processes of the body change the chemicals from relatively innocuous substances into reactive intermediates which in as yet unknown fashion, trigger the chain of events which finally result in tumor formation. In other words, chemical carcinogenesis is an effect of "failed" detoxification. [Pg.77]

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