Carcinogenesis in the Skin

Coggle, J.E. and J.P. Williams. 1990. Experimental studies of radiation carcinogenesis in the skin a review. Inter. Jour. Radiation Biol. 57 797-808. 

Coggle JE, Williams JP. 1990. Experimental studies of radiation carcinogenesis in the skin A review. 

Cancer occurs when the growth and function of cells are out of control in relation to normal tissue. The combination of genetic alterations and environmental toxins is the most frequent contributor to the process of carcinogenesis. In the development of skin cancer, the risk factors are categorized as environmental (solar UV radiation), genetic (family history), immunosuppression, and previous history of melanoma.10... 

Toxicology. Indenol(l,2,3-ci)pyrene (IP) is a complete carcinogen and an initiator for skin carcinogenesis in the mouse. ... 

Schweizer, J., Loehrke, H., Elder. L. Goerttler, K. (1987) Benzoyl peroxide promotes the formation of melanotic tumors in the skin of 7,12-dimethylbenz[a]anthracene-initiated Syrian golden hamsters. Carcinogenesis. 8. 479-482... 

Shubik P, Pietra G, Della Porta G. 1960. Studies of skin carcinogenesis in the Syrian golden hamster. Cancer Res 20 100. 

Berenblum, I., and Shubik, P. (1949). A new quantitative approach to the study of the stages of chemical carcinogenesis in mouse skin. Br J Cancer 1, 383-390. 

Slaga, T. J., Fischer, S. M., Weeks, C. E., Klein-Szanto, A. J., and Reiners, J. (1982). Studies on the mechanisms involved in multistage carcinogenesis in mouse skin. J Cell Biochem 18, 99-119. 

For p-carotene (1) supplementation studies, the findings from completed large scale trials indicate no overall benefits in well nourished human populations on the middle to late stages of carcinogenesis or on the incidence of cardiovascular disease [58]. The clinical use of P-carotene (1) as treatment for erythropoietic protoporphyria, in which C>2 is produced via sensitisation of free porphyrins in the skin, is well established [59]. 

Van Duuren et al. also noted that rutin, a tobacco component, also inhibited B[a]P carcinogenesis in the mouse skin-painting bioassay. From the results of their biological experiments on cocarcinogenesis (simultaneous and repeated application of an agent, in this case 1,2-benzenediol [catechol]), with B[fl]P, Van Duuren et al. (4029) deduced that 1,2-benzenediol (catechol) showed remarkable cocarcinogenic activity with B[fl]P. They reported ... 

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