Pesticide carcinogenesis evaluation

Bolognesi C, Bonatti S, Began P, et al. 1994. Genotoxicity of some pesticides used in floriculture comparative evaluation of active ingredients and agrochemical formulations. Carcinogenesis 35 144. 

The study of xenobiotic metabolism has developed rapidly during the past few decades. These studies have been fundamental in the assessment of drug efficacy, safety, and design of dosage regimens in the development of food additives and the assessment of potential hazards of contaminants in the evaluation of toxic chemicals and in the development of pesticides and herbicides and their metabolic fate in insects, other animals, and plants. The metabolism of many xenobiotics is fundamental to many toxic processes such as carcinogenesis, teratogenesis, and tissue necrosis. Often the same enzymes involved in... 

In 1969, the Technical Panel on Carcinogenesis, an advisory committee to the Commission on Pesticides and Their Relationship to Environmental Health,published its evaluation of available reports on the carcinogenicity of over 100 pesticides. On the basis of testing for tumor induction conducted adequately in two mammalian species, the panel listed three chemicals as not positive. For similar testing that involved at least one mammalian system, the panel listed 32 chemicals as having increased the tumor incidence relative to controls with significance at the 0.02 level (B, Cl, and C2). 

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