Carcinogenesis esophageal

A toxic component of braken fern, perhaps either quercetin (105) or ptaquiloside, a glucoside (106), has a mixed history of carcinogenicity. It is sometimes impHcated in an increased incidence of bladder cancer in animals and esophageal cancer in humans. Multiple other dietary components seem to either promote or interfere with its action, and the significance of braken fern in human carcinogenesis remains unproven. 

Both l-nitroso-3,5-dimethylpiperazine and l-nitroso-3,4,5-trimethylpiperazine induced a high incidence of thymic leukemia in rats within 6 months (23). The 4-acetyl derivative of the former induced esophageal tumors in the same time, while the 4-benzoyl derivative was a very much weaker carcinogen, giving rise to only a few tumors of the forestomach after almost 2 years. These contrasting results are difficult to reconcile with any simple mechanism of carcinogenesis. 

Luo, X.M., H.J. Wei, and S.P. Yang. 1983. Inhibitory effects of molybdenum on esophageal and forestomach carcinogenesis in rats. Jour. Natl. Cancer Inst. 71 75-80. 

Hatakeyama H, Kondo T, Fujii K, et al. (2006) Protein clusters associated with carcinogenesis, histological differentiation and nodal metastasis in esophageal cancer. Proteomics 6, 6300-16. 

Li ZG, Hong T, Shimada Y, Komoto I, Kawabe A, Ding Y, Kaganoi J, Hashimoto Y, Imamura M. 2002. Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis 23 1531-1536. 

Dietary Factors Affecting Biological Responses to Esophageal and Colon Chemical Carcinogenesis... 

Table IX. Riboflavin (B ) Deficiency in the Rat Enhanced Esophageal Carcinogenesis ...

Chen X, Mikhail SS, Ding YW, et al. 2000. Effects of vitamin E and selenium supplementation on esophageal adenocarcinogenesis in a surgical model with rats. Carcinogenesis 21(8) 1531-1536. 

Widjajakusuma etal. 1973). In rats, the addition of molybdenum at either 2 or 20 mgL drinking water inhibited esophageal and fore-stomach carcinogenesis (Luo etal. 1983). Further studies are necessary to replicate all these effects (Bogden et al. 

Chen X, Yang CS. Esophageal adenocarcinoma a review and perspectives on the mechanism of carcinogenesis and chemoprevention. Carcinogenesis 2001 22 1119-1129. 

Chen, X. et al.. Oxidative damage in an esophageal adenocarcinoma model with rats. Carcinogenesis, 21 (2), 257, 2000. 

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