Carboxymethyl benzylamide sulfonate dextran

By analogy with the results obtained with CMDBS (Carboxymethyl benzylamide sulfonate dextrans), it is interesting to know the effects of P4 terpolymer of malic acid derivatives in the regeneration model of EDL (Extensor digitorum longus ) rat muscle " . ... 

Fig. 39 Synthesis of carboxymethyl dextran sulfate (CMDSu), carboxymethyl dextran ben-zylamide sulfate (CMDBSu) and carboxymethyl dextran benzylamide sulfonate sulfate (CMDBSSu), respectively...

Table 14 Composition, anticoagulant (antithrombic), and anticomplementary activities of dextran derivatives with different DS of carboxymethyl (CM), benzylamide (B) and sulfonate/sulfate (S) functions ...

The synthesis of CMDBSSu involves the random carboxymethylation of hydroxyl groups on the glucose units, the benzylamidation of some of the carboxylic groups with benzylamine in the presence of N-ethoxycarbonyl-2-ethoxy-l,2-dihydroquinoline (EEDQ) to carboxymethyl dextran benzylamide (CMDB), the sulfonation of phenyl rings and sulfation of remaining hydroxyl groups at the polymer backbone (Fig. 39, [108,222]). 

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