Carboxyl Cell growth

Acetyl-CoA carboxylase (ACCase) carboxylates acetyl-CoA into malo-nyl-CoA and therefore represents the first committed step in fatty acid biosynthesis. ACCase is a multimer essential for cell growth whose components are highly conserved among bacteria, making it a promising broad-spectrum target [8]. 

Marciano, D., Benbaruch, G., Marom, M., Egozi, Y., Haklai, R., and Kloog, Y. (1995). Farnesyl derivatives of rigid carboxylic acids-inhibitors of Ras-dependent cell-growth. 

Like helminths, some protozoans also require polyamines for their cell growth, membrane stabilization and as cofactors for macromolecular synthesis. Trypanosomes have been found to possess putrescine and spermidine, but not spermine. The precursor of the polyamine biosynthesis in protozoans is ornithine, which is de-carboxylated in the presence of ornithine decarboxylase to form putrescine. Other polyamines are formed from putrescine as discussed in chapter 2 (Sec. 5.3). 

Aza-epothilone 1 (( )-(25,95,7 0f ,77f ,745)-10,14-dihydroxy-9,l 1,13,13-tetramethyl-2-[2-(l,2-dimethyl-benzimidazol-5-yl]-12,16-dioxo-l-oxa-5-aza-cyclo-hexadecane-5-carboxylic acid tert-butylester) and its 7,8-dehydro analogue 2 are potent inhibitors of human cancer cell growth, and represent a structurally new class of natural product-derived microtubule-stabilizing agents. 

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