5-Carboxy-4-methoxycarbonyl-1 -

Lumazine, 6,7-bis(methoxycarbonyl)-l,3-dimethyl-synthesis, 3, 314 Lumazine, 6-carboxy-7-hydroxy-properties, 3, 277 Lumazine, 7-carboxy-6-hydroxy-properties, 3, 277 Lumazine, 6-chloro-1,3-dimethyl-reactions, 3, 292 synthesis, 3, 290, 296 Lumazine, 7-chloro-l,3-dimethyl-reactions, 3, 292 synthesis, 3, 296... 

Menthyloxycarbonyl- 324 4-Methoxy- 678 4-Methoxycarbonyl- 289 4-Methyl- 678 4 -Methyl-2-carboxy-159 4-Methylsulfinyl- 674 4-Methylthio- 674... 

Alkylation of ll-mercaptopyrido[l,2-h]cinnolin-6-ium hydroxide inner salts (e.g., 41) with ethyl bromoacetate gave ll-(ethoxycarbonylmethyl(thio derivatives 64 (R = H), which could be hydrolyzed to the ll-(carboxy-methyl)thio derivative or back to the starting compound 41 (74JHC125). Hydrolysis of the ll-bis(methoxycarbonyl)methylene 66 (R = H), and 2-cyano derivatives of 17 (R = H) in boiling HCl afforded 11-methyl and 2-carboxylic acid derivatives, respectively (74JHC125). The 2-nitro derivative of 17 (R = H) was reduced to the 2-amino derivative over Pd/C with NaBH4 in aqueous methanol, and the 2-amino group was acylated with acetic anhydride at 100°C. 

Brom-5-formyl-l-( 4-methoxy-henzyl)-imidazol l-Benzyl-4-brom-5-carboxy-...946 /-Benzyl-4-brom-5-mercapto-...946 4-Brom-5-methoxycarbonyl-]-methyl-...1047 1033 50% 67% 68% 50% ... 

Die Reaktion kann auch einen umgekehrten Verlauf nehmen (s. S. 790). 4-Carboxy-benzofurazan-l-oxid (R = OH) sowie 4-Methoxycarbonyl- (R = OCH3) bzw. 4-Ami-nocarbonyl-benzofurazan-l-oxid (R = NH2) lagern sich offensichtlich nicht in die zu erwarten-den 3-substituierten 7-Nitro-2,l-benzoxazole um274 moglicherweise sind in diesen Fallen die Benzofurazan-1-oxide thermodynamisch stabiler. 

The aromatization pathways of 1-carboxy-, 1-methoxycarbonyl-, 1-formyl-, 1-(hydroxymethyl)-, and l-(2-hydroxy-2-propyl)benzene oxides (218, 223,... 

Keywords 2-amino-2 -hydroxy-3,-(methoxycarbonyl)-l,l -binaphthyl, SN2 substitution, 2-metliy lamino-2 -hydroxy-3 -carboxy-1,1 -binaphthyl... 

Water (8 ml), methanol (8 ml) and THF (8 ml) are added to (2S,4S,5R)-2,4-diphenyl-3-(4-nitrobenzenesulfonamido)-5-methoxycarbonyl-l,3-oxazolidine (1.50 g, 3.19 mmol). Potassium carbonate (1.018 g, 7.71 mmol) is then added. The resulting mixture is stirred at 20°-25°C until complete by TLC. After 5 h the reaction is complete and the reaction mixture is extracted with basic methylene chloride (2 times). The aqueous phase is then acidified with hydrochloric acid and extracted with ethyl acetate. The ethyl acetate phase is then washed with water, saline and dried over magnesiuim sulfate. Concentration of the organic phase (ethyl acetate) gives the (2S,4S,5R)-2,4-diphenyl-3-(4-nitrobenzenesulfonamido)-5-carboxy-l,3-oxazolidine, melting point 61°-65°C. 

Carboxy-6-hydroxythiazolo[2,3-/ [ 1,6]-naphthyridin-4-ium-3-carboxylate (152) (beminamycinic acid) underwent exhaustive methylation to afford methyl 8-methoxy-6-(l-methoxycarbonyl-2-methylthiovinyl)-5-oxo-5,6-dihydro-1,6-naphthyridine-2-carboxylate (153) (Mel, Ag20 low yield)293 or hydrogenolysis to furnish a separable mixture of 6-(l-carboxylatoethyl)-8-hydroxy-l,2,3,4-tetrahydro-l,6-naphthyridin-6-ium-2-carboxylic acid (154) and 8-hydroxy-1,2,3,4-tetrahydro-l,6-naphthyridine-2-carboxylic acid (155) (Raney Ni, NaOH, H20 unstated yields).274... 

Methoxycarbonyl-l-naphthols used to prepare 5-methoxycarbonyl (and related)-2/f-naphtho[l,2- Z>]pyrans can be synthesized from 3-carboxy-l,4-dihydroxy-naphthalene (which is commercially available), or may be prepared by the sequence... 

APM-Ace [2-carboxy-p-(A-( -methoxycarbonyl-2-phenyl)ethylcarbamoyl)]ethanaminium 6-methyl-4-oxo-1,2,3-oxathiazin-3-ide-2,2-dioxide L-Phenylalanine, L-a-aspartyl-2-methyl ester compound with 6-methyl-1,2,3-oxathiazin-4(3H)-one 2,2-dioxide (1 1)... 

Carbohydrase and Protease, Mixed (Bacillus licheniformis var.), 20 Carbohydrase and Protease, Mixed (Bacillus subtilis var. including Bacillus amyloliquefaciens), 20 [2-Carboxy-P-(A-(h-methoxycarbonyl-2-phenyl)ethylcarbamoyl)]ethanaminium 6-Methyl-4-oxo-l,2,3-oxathiazin-3-ide-2,2-dioxide, 5... 

Nucleophilic substitution of the diazo group is practically the only method for the production of nitro derivatives of tetrazole [392, 436 143], 5-Nitrotetrazole itself was isolated and identified in the form of metallic salts [436-440, 442, 443], The mechanism of substitution of the diazo group by a nitro group in heterocyclic compounds has not been studied specially. As already mentioned, in many cases the reaction takes place as catalytic nucleophilic substitution and does not require the use of a catalyst (copper salts) [392,444], The results from investigation of the kinetics of the substitution of the diazonium group by the nitro group in compounds of the benzene series make it possible to suppose that the diazonitrite is formed intermediately and quickly reacts with a second nitrite anion [392,444], Some difference between the kinetics of the reaction of 3-diazonium-5-carboxy-l,2,4-triazole and 3-diazonium-5-methoxycarbonyl-l,2,4-triazole with sodium nitrite in hydrochloric acid and the analogous process in the benzene series is probably due to prototropic... 

Aza-l, 3-dienes, 1,1-bistrifluoromethyl-, cycloaddition to diazomethane, 60, 39 2-Aza-1.3-dienes, 3-carboxy-, formation, dimerization, 57, 43 2-Aza-l, 3-dienes, 3,4-dicarboxy-, formation, cycloadditions, 57, 43 2-Aza-l, 3-dienes, 4-dimethylamino-3-methoxycarbonyl-1, l-di(methylthio)-, 57, 29... 

Carboxy-3-methyl- E14a/3, 499 [CH20 + HS-CH2-CH(NHR) —COOH] 4-Methoxycarbonyl- E14a/3, 501 [CH20+HS-CH2-CH(NH2)-COOR]... 

Carboxy-2-isopropyl-l -hydroxy-E17b. 1040 [l,2-(OTos)2 — cyclobuten/Br2 NaOH] 2-Ethoxy-l -methoxycarbonyl- E19b, 1139 (En + Carben)... 

Carboxy-6-(carboxy-methyl)-E19d, 606 (H - Li - COOH) 2-Carboxy-5-methoxycarbonyl- ... 

Bicyclo[4.1.0]heptan a f/-7-Brom-iyn-7-carboxy- E19d, 866 (Br - Li + C02) Bicyclo[l.l.l pentan 3-Brom-l-(methoxycarbonyl-methyl)-E17e, 54 (Tricyclo[1.1.1.01,3]pentan + Br-CH2-COOR)... 

Bis-[3-carboxy-propyl)- VI/2, 804 (Methoxycarbonyl-methyl)-(2-methoxycarbonyl-propyl)- E6a, 379 [HS-CH2-COOR +... 

C9IIgOs Peroxid (Continuation) Benzoyl-methoxycarbonyl- E13/1, 910 (Cl O-O-CO-R) Phthalsanre 3-Hydroxy- -2-methylester VI/lc, 440 Propansaure 3-(4-Hydroxy-phenyl)-2-oxo- Vl/ld, 88 Tropon 3-Carboxy-5-methoxy-IV/la, 516... 

H-l,4-Benzothiazine 2-(Carboxy-methyl)-3-oxo-3,4-di hydro- E9a, 455f. (2-SH — anilin + Malein-saure), 460 (2-SH —anilin + 2-Br-butandisiiure) 2,1-Benzothiazol 3-Methoxy-7-methoxycarbonyl- E8a, 870 (Oxa - Thia)... 

Cuban l-Carboxy-4-methyl- El7e, 324 (2-Br —keton-Ringvereng.) Cyclooctatetraen Methoxycarbonyl-IV/5a, 500 E17c, 2201 (7-COOR — bicyclo[4.2.0]ocia — 2,4,7-trien/hv)... 

Propan l-(2-Methoxy-5-methyl-phenyl)-2-nitro-l-nitroso-(dimer) X/l, 74 Propansaure 2-Amino-3-(4-hydroxy-phenyl)- -(carboxy-methylamid) XV/2, 195, 617 3H-Pyrazol 3-Cyclopropyl-4,5-dimethoxycarbonyl-3-methyl-E14, 994 (R2C = N2 4- In) Pyrimidin 2,6-Dimethoxy-5-(2-methoxycarbonyl-ethenyl)-4-methyl- E9b/2, 224f. 

Oxa-4-aza-bicyclo 3.1.0 hexane (17 .3R,55,65)-3-tert.-Butyl-6-carboxy-4-methoxycarbonyl-E21c. 3231 (COOR - COOH)... 

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