3- Carboxamido analogue

The 3-carboxamido analogue of cyclazosine (a benzomorphan without the C and D rings of morphine) where the -OH group in position 8 of the aromatic ring was substituted by a carboxamido group... 

Other recently studied compounds are the 3-carboxamido analogues of morphine and nactrexone [49]. 

When treated with HNO3 in TFA, 2-cyano-3-hydroxyimidazole 1-oxide 310 (R1 = CN) is nitrated at the 4-position and the cyano group hydrolyzed, while the 2-carboxamido analogue 310 (R1 = CONH2) is dinitrated at the 4- and 5-position with simultaneous deoxygenation (1992ZOR2424). 

The 3-carboxamido derivatives of pyrimido[6,l-c][l,4]oxazine-6,8-diones 164 (Y = 0), as with their nitrogen and sulfur-containing analogues, are matrix metalloproteinase inhibitors useful for treating MMP-13 enzyme-mediated diseases (e.g., heart failure, multiple sclerosis, and macular degeneration) <2004W02004/014354>. 

In search of novel and more effective antibacterial agents, numerous /1-lactam antibiotics bearing a pyridazine core have been synthesized mainly in Japan. Thus, the penicillin derivative (125) characterized by a 3-hydroxypyridazine-4-carboxamido subunit has been patented as a broad-spectrum bactericide [342-345] likewise, the corresponding cephalosporin analogue has been claimed in a patent [346]. 

Replacing the sulfonic acid 27 with the appropriate carboxy-, carboxamido-, sulfonyl-, or sulfon-amido-4-nitrochlorobenzene leads to analogues described in [61], [62],... 

Fluoro-, amino- (2), -carboxamido, -nitro, -ethyl, -ethynyl, -amino, and -cyano (3) 2, 3 -unsaturated pyrimidine analogues (I) of the current invention have been prepared (I) and are described. 

Nucleoside analogues of nicotinamide continue to attract attention. 2-Carboxamido-6-(P-D-ribofuranosyl)pyridine has been prepared in a way similar to that noted in Vol. 21 (p.211) for the isomer (52),i04 but an alternative approach was also used.iOS.i06 This new method was also applied to make (52). as outlined in Scheme 14. During the borohydride reduction two... 

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