Carbon cycle microbial pathways

Kozarich JW (1988) Enzyme chemistry and evolution in the )S-ketoadipate pathway. In Microbial Metabolism and the Carbon Cycle (Eds SR Hagedorn, RS Hanson, and DA Kunz), pp. 283-302. Harwood Academic Publishers, Chur, Switzerland. 

Diacids. The microbial generation of mahc, fumaric, and succinic acid essentially imphes Krebs cycle pathway engineering of biocatalytic organisms to overproduce oxaloacetate as the primary four-carbon diacid that subsequently undergoes reduction and dehydration processes (Scheme 2.9). The use of these four-carbon diacids as intermediate chemicals and the state of their desirable microbial production is briefly outlined. 

The turnover of amino acids in microbial cultures increases in stationary phase. If it is, at least, more important during slow growth and under natural stresses, it follows that isotopically depleted products from the ends of the biosynthetic pathways will be recirculated more frequently than in the continuously illuminated, optimal cultures of Anabaena. Greater recycling will reduce the removal of carbon skeletons from the tricarboxylic acid cycle and result in the importation of less C-enriched material from that source. Together, these processes should lead to the accumulation of " C-enriched... 

---