Carbohydrates trisaccharides

In tandem with his studies of polysaccharides, Stacey had a research group investigating the chemistry of the unusual sugars found as components of carbohydrate macromolecules. In this context, derivatives of simple sugars, di- and trisaccharides, uronic acids, deoxy sugars, amino sugars, sugar sulfates, and phosphates were studied. 

Amino Acids and Peptides Carbohydrate Chemistry Parti Mono-, Di-, and Trisaccharides and Their Derivatives... 

The trichloroacetimidate method has also been used to prepare bivalent Lex oligosaccharides to study the conformational details of carbohydrate clusters by NMR spectroscopy [437] TWo Le trisaccharides were covalently linked through... 

The trisaccharide-hexapeptide partial structure (151) of aleukemia-virus envelope glycoprotein, which was obtained from 46 (see Section 11,2) via saccharide and carboxyl deprotection, has also been coupled to BSA to furnish a synthetic glycoprotein 152 containing 12% of carbohydrate in the form of the trisaccharide (19). 

The branched trisaccharide 1 was defined as the minimal carbohydrate epitope for effective binding to anti-GAS Abs [79]. The bound conformation of 1 in complex with the IgG mAb Strep 9 was investigated by transferred NOE experiments and found to correspond to a local minimum conformation, which differed from the predominant conformation in the free state by a rotation around the xj/ angle of the o -(l-2) linkage [123]. STD-NMR ex-... 

Kerekgyarto, J. Vanderven, J. G. M. Kamerhng, J. P. Liptak, A. Vliegenthart, J. F. G., Synthesis of a Selectively Protected Trisaccharide Building Block That Is Part of Xylose-Containing Carbohydrate Chains from N-Glycoproteins. Carbohydr. Res. 

The most important result, however, is the binding of the trisaccharide tri-N-acetylchitotriose, as the model proposed for substrate binding and enzymic hydrolysis is based on this compound. The three substituted /3-D-glucopyranose residues are labeled A, B, and C in Fig. 2. Two observations are the same as for 2-acetamido-2-deoxy-D-glucose residue C has the same binding as the /3-d anomer, and the resulting shift of amino acid residue 62 (L-tryptophan) is 0.75 A. The hydrogen bonds between lysozyme and carbohydrates A and B are shown in Fig. 2 and listed in Table IV. Residue A, which is located... 

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