Carbohydrates in the synthesis

This methodology opens up an efficient stereoselective access to chiral piperidi-none derivatives 60 which have opposite configuration compared to compounds 46 obtained by the tandem Mannich-Michael reaction sequence described in Section 4.3.2. The high diasteroselectivity and regioselectivity in these reactions once again illustrate the stereodifferentiating potential of carbohydrates in the synthesis of chiral heterocyclic systems. 

THE USE OF CARBOHYDRATES IN THE SYNTHESIS AND CONFIGURATIONAL ASSIGNMENTS OF OPTICALLY ACTIVE, NON-CARBOHYDRATE COMPOUNDS... 

Inch, T. D., The Use of Carbohydrates in the Synthesis and Configurational Assignments of Optically Active, Non-carbohydrate Compounds, 27, 191-225... 

Inch, T D, The use of carbohydrates in the synthesis and configurational assignment of optically active non-carbohydrate compounds, Adv. Carbohydr. Chem. Biochem., 27, 191-225, 1972. 

N. K.Kochetkov, A.F.Sviridov, H.S.Ermolenko, et al., "Carbohydrates in the Synthesis of Natural Compounds",(Nauka Moscow, USSR), 1984. 

This year has seen the application of carbohydrates in the synthesis of enantiomerically pure acids, amino acids and diols, including those containing isotopic labels. l,2 5,6-Di- >-isopropylidene-a-D-glucofuranose has been converted to diastereomerically pure epoxide 102 and diol 103 and the reactivity of these units has been exploited for the synthesis of enantiomerically pure labelled glycine and acetic acid, as well as 1,2-diols (Scheme 2 )P ... 

The use of carbohydrates in the synthesis of a-aminoacids, covering both situations in which the sugar is used as a chiral precursor, and where it acts as a chiral auxiliary, has been reviewed.73 Reviews have also been published, in Russian, on the stereoselective synthesis of and y-aminoacids and polyoxins,74 and of uncommon aminoacids such as streptothricin components,73 from sugars. 

A more recent international journal. Journal of Carbohydrate Chemistry, was introduced in 1982. It requires camera-ready copy and is devoted primarily to the organic and physical chemistry of carbohydrates, such as novel synthetic methods mechanisms involved in carbohydrate reactions uses of carbohydrates in the synthesis of natural products, drugs, and antibiotics use of carbohydrates as synthetic reagents separation methods as applied to carbohydrate reactions and synthesis spectroscopic and crystallographic structure studies of carbohydrates molecular modeling studies and the chemistry of carbohydrate polymers, oligosaccharides, polysaccharides, and glycoconjugates. 

The demonstrated organocatalyzed cascade sequences indicate the great potential of unprotected carbohydrates in the synthesis of highly functionalized biomimetic structure motifs by operationally simple, one-pot protocols. 

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