Carbohydrates carcinogenesis

Carcinogenesis A risk of carcinogenesis may attend the IM injection of iron-carbohydrate complexes. 

Our laboratory has completed a series of studies designed to evaluate the simultaneous effects of dietary protein and fat on 7,12-dimethylbenz(a)anthracene (DMBA)-induced breast cancer in rats. Sprague-Dawley female rats were assigned to nine diets in a 3 x 3 factorial arrangement with protein (casein) at 8, 16, and 32% of kcals and fat (corn oil) at 12, 24, and 48% of kcals. As fat content was increased, all nutrients other than carbohydrate were adjusted to remain constant with respect to calories. Forty rats were assigned to each diet for each of three experiments (Figure 1) to examine initiation, promotion, and the combined phases of chemically-induced carcinogenesis. 

GerbrachtU, Einig C, Oesterle D, et al. 1990. Di(2-ethylhexyl)phthalate alters carbohydrate enzyme activities and foci incidence in rat liver. Carcinogenesis 11 (12) 2111-2115. 

Thiamine Differentially Modifies Transcript Expression Levels of Genes Involved in Carbohydrate Metabolism, Lipid Metabolism, Vascular Physiology and Carcinogenesis in the Liver... 

Figure 35.3 Genes modified by thiamine intervention in OLETF rats. Thiamine modified transcript expression levels of genes implicated in carbohydrate metabolism, lipid metabolism, vascular physiology and carcinogenesis in the liver of the Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Tanaka and Kohda unpublished data.

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