Carbohydrate mimetic libraries

Reductive amination was the first method described for amine production on solid phase. It was first mentioned in 1987 by Coy et al. [260,261]. They used a combination of Na(CN)BH3 and HOAc for the subsequent reduction of intermediately formed imides in the synthesis of somatostatin octapep-tide analogs. Due to its early development, this alkylation method has found entry to the synthesis of diverse substance classes like N-terminal-modified peptides, carbohydrate mimetics [262], glycopeptides [263,264], oligonucleotides [265], and of course polyamines [174,175,222,232,248,266,267]. For the same reasons as the amide reduction approach, it is powerful enough to be used in the production of several compound libraries [177,262-264, 268]. 

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