Carbohydrate glycogenolysis

Il.f.l.1. Insulins. Insulin is the most effective of diabetes medications. Insulin has profound effects on carbohydrate, protein, fat metabolism and electrolytes. It has anabolic and anticatabolic actions. In a state of insulin deficiency, glycogenesis, glucose transport, protein synthesis, triglyceride synthesis, LPL activity in adipose tissue, cellular potassium uptake all decrease on the other hand, gluconeogene-sis, glycogenolysis, protein degradation, ketogene-sis, lipolysis increase. 

The goal of glycolysis, glycogenolysis and the TCA cycle, is to conserve energy as ATP from the catabolism of carbohydrates. If cells have sufficient supplies of ATP then these pathways and cycles are inhibited under such conditions the liver will convert a variety of excess molecules into glucose and/or glycogen. 

A. By 2-3 hours after a high-carbohydrate meal, the patient s glycogen stores would be filled. Glucagon would stimulate glycogenolysis, and blood glucose levels would rise. 

Carbohydrate metabolism. Insulin stimulates glycogen synthesis. At the same time it inhibits glycogenolysis and gluconeogenesis. The overall result of these activities is the storage of excess glucose. 

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