Carbocyclic thromboxane

Toda, N. (1984). Responses of human, monkey and dog coronary arteries in vitro to carbocyclic thromboxane A2 and vasodilators. Br. ]. Pharmacol, 83, 399-408... 

Smith, III., E.F., Lefer, A.M. and Nicolaou, K.C. (1981). Mechanisms of coronary vasoconstriction induced by carbocyclic thromboxane A2. Am. ]. Physiol, 9, H493-H497... 

Twoard, R. and Perzbom, E. (1982). Relaxation of carbocyclic thromboxane A2-induced contractions of isolated coronary arteries by nifedipine. Naunyn Schmeidebergs Arch. Pharmacol, 318, 249-251... 

Toda, N., 1982 Mechanism of action of carbocyclic thromboxane A2 and its interaction with prostaglandin 12 and verapamil in isolated arteries. Circ. Res. 51, 675-682. 

Linoleic acid is one of the most important polyunsaturated fatty acids it is the essential lipid precursor to many vital biomolecules, such as prostaglandins, thromboxanes, lipoxins, and prostacyclins (1-5). All of these linoleic acid metabolites are unique molecules with either carbocyclic systems containing chiral carbon centers or unsaturated C-C systems of specific geometric configurations. These fatty acid metabolites perform highly specialized physiologic roles (6,7). 

Some compounds with thromboxane-like structure have been screened for agonist activity on thromboxane sensitive systems. Carbocyclic TXAj [155,245,246] behaved as a potent TXA2 agonist on the vasculature (isolated cat coronary artery) but rather as an antagonist on arachidonic acid induced platelet aggregation. The TXA, analogue, 9a-homo-(l l,12)-deoxa-(l l,12)-methylene thromboxane A, showed weak TXA 2-like properties with respect to vasoconstriction but had no effect on platelet aggregation [247]. 

Eicosanoids are unsaturated C20 acids. They are aliphatic (leucotrienes) or contain either a five-membered carbocyclic ring (prostaglandins, prostacyclins) or a six membered 0-heterocyclic ring (thromboxanes). Hydroxy, keto, and epoxy groups may be present. 

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