Carbobenzoxy

Another name for the benzyloxycarbonyl group is carbobenzoxy This name and Its abbreviation Cbz are often found in the older lit erature but are no longer a part of lUPAC nomenclature... 

CARBOBENZOXY CHLORIDE CARBOFURAN CARBON DIOXIDE CARBON DISULFIDE... 

Chemical Designations - Synor ms Carbobenzoxy Chloride Chloroformic Acid, Benzyl Ester Benzylcarbonyl Chloride Benzyl Chlorocarbonate Chemical Formula C HjCH OCOCl. Ohservahle Characteristics - Physical State (as normally sh ed) Liquid Color. Colorless Odor. Irritating sharp, penetrating. 

Directly from a carbobenzoxy-protected amine 1,4-cyclohexadiene, Pd/C, (B0C)20, EtOH, rt, 86-96% yield. ... 

V. -(l-Carbobemoxy-4 -piperidyl)propionyl chloride. /3-(iV-carbo-benzyloxy-4-piporidyl)ethyl 3-indolyl ketone (208) was obtained similarly by the condensation of ]3-(A -carbobenzoxy-4-piperidyl)-propionyl chloride with indole magnesium bromide in ether. ... 

Treatment of the piperidine 74, obtainable from an aminonitrile such as 73, under N-methylation conditions leads to the dimethylamino derivative 75. The carbobenzoxy protecting group is then removed by catalytic hydrogenation. Reaction of the resulting secondary amine 76 with cyclohexene oxide leads to the alkylated trans aminoalcohol. There is thus obtained the anti-arrhythmic agent transcainide (77) [18]. 

Preparation of L-(-)-y-Benzyloxycarbonylamino-a-Hydroxybutyric Acid L-(-)-7-amino-o-hydroxybutyric acid (7.4 g, 0,062 mol) was added to a solution of 5.2 grams (0.13 mol) of sodium hydroxide in 50 ml of water. To the stirred soiution was added dropwise at 0 -5°C over a period of 0.5 hour, 11.7 grams (0.06B mol) of carbobenzoxy chloride and the mixture was stirred for another hour at the same temperature. The reaction mixture was washed with 50 ml of ether, adjusted to pH 2 with dilute hydrochloric acid and extracted with four BO ml portions of ether. The ethereai extracts were combined, washed with a small amount of saturated sodium chloride solution, dried with anhydrous sodium sulfate and filtered. The filtrate was evaporated in vacuo and the resulting residue was crystallized from benzene to give 11.6 grams (74%) of colorless plates MP 78.5° to 79.5°C. 

Preparation of 1-[L-l-)-y-Bemyloxycarbonylamino-a-Hydroxybutyryl]-6 -Carbobenzoxy-kanamycin A A solution of 1.6 grams (4.6 mmol) of L-(-)-7-benzyloxycarbonylamino-... 

A 0.60 g portion of N-carbobenzoxy-D-phenylglycine is dissolved in 10 ml of dry tetra-hydrofuran. The solution is cooled in an ice-salt bath, and to it is added 0.29 ml of tri-ethylamine with stirring over a period of 10 minutes, followed by 0.29 ml of isobutyl chloroformate, after which stirring is continued for 10 minutes at -5°C. During this time,... 

The reaction product mixture is a homogenous solution having a pH of about 6. It is evaporated under vacuum to a semisolid residue. To the residue are added 35 ml of water and a few drops of triethylamine to raise the pH to 8. The aqueous solution obtained thereby is extracted successively with 50 ml and 35 ml portions of ethyl acetate, the pH being adjusted to 2 at each extraction with hydrochloric acid. The extracts are combined, filtered, dried over sodium sulfate, stripped of solvent, and evaporated under vacuum. The product is 7-(N-carbobenzoxy-D-o -aminophenylacetamido)cephalosporanic acid in the form of a yellow-white amorphous solid weighing 1.10 g. 

N-Carbobenzoxy-L-prolyl-e-N-p-toluenesulfonyl-L-lysyl-glycinamide N-Carbobenzoxy-L-glutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-azide N-Carbobenzoxy-S-benzyl-L-cysteinyl-L-phenylalanyl azide... 

The mixture is allowed to stand for 2 days at 20°C, after which twice its volume of ethyl-acetate is added and the resultant precipitate then washed with warm methanol. There are obtained 45 parts by weight of N-carbobenzoxy-S-benzyl-L-cysteinyl-L-phenylalanyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-prolyl-e-N-p-toluenesulfonyl-L-lysyl-glycinamide MP 222 C. 

Chemical Name [[(8 )-1,6-dimethylergolin-8-yl] methyl] carbamic acid phenylmethyl ester Common Name Methyl-N-carbobenzoxy-dihydro-lysergamine Structural Formula ... 

N-Carbobenzoxy-S-benzyl-L-cysteinyl-L-phenylalanyl azide Felypressin... 

N-Carbobenzoxy-L-glutaminyi-L-aspara-ginyl-S-benzyl-L-cysteinyi azide Felypressin Ornipressin... 

PEPTIDE SYNTHESES USING N-ETHYL-5-PHENYLIS0XAZ0LIUM-3 -SULF0NATE CARBOBENZOXY-l-ASPARAGINYL-l-LEUCINE METHYL ESTER AND JV-CARBOBENZOXY-3-HYDROXY-l-PROLYLGLYCYLGLYCINE ETHYL ESTER... 

A. Carbobenzoxy-L-asparaginyl-L-lewine Methyl Ester. A mixture of 2.024 g. (0.0080 mole) of A -ethyl 5 phenylisoxazolium-3 -sulfonate [Isoxazolium, 2-ethyl-5-(3-sulfophenyl)-, hydroxide, inner salt] (Note 1) and 20 ml. of nitromethane (Note 2) is prepared in a 50-ml., glass-stoppered Erlenmeyer flask at room temperature and stirred vigorously... 

Carbobenzoxy-L-asparagine (obtained from the Aldrich Chemical... 

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