Carbimazol - Carbimazole

Carbimazole Carbimazole, the ethyl ester of 3-methyl-2-thioimidazolin-l-carboxylic acid (25.2.7), is synthesized by a simultaneons reaction of ethylenacetal of bromoacetaldehyde with methylamine and potassium isocyanate, forming 3-methyl-2-imidazolthione (25.2.6), which is further acylated at the nitrogen atom by ethyl chloroformiate, giving the desired product (25.2.7) [17-19]. 

In three other cases reported in the same paper, severe hyperthyroidism responded severally to treatment with carbimazole, carbimazole plus lithium, or propylthiouracil. In one case amiodarone therapy was restarted after prophylactic subtotal thyroidectomy. 

Efforts to improve the taste and decrease the rate of release of MMI led to the development of 1-carbethoxy-3-methylthioimidazole (carbimazole). Carbimazole, the pro-drug derivative of methimazole, gives rise to methimazole in vivo and is used in the same dosage. 

Captopril 3, 128 Caramiphen 1, 90 Carbacephal othin 1, 420 Carbadox 390 Carbamazepine 403 Carbantel 57 Carbaprost 1 Carbazeran 195 Carbenicillin l, 414 2, 437 Carbetidine 1, 90 Carbidopa 2 119 Carbimazole 1, 240... 

Both drugs, MMI and PTU, are actively concentrated by the thyroid gland. Intrathyroidal concentrations of MMI are in the range of 5 x 105 M. There is no difference in intrathyroidal concentrations of MMI 3-6 and 17-20 h after ingestion of 10 mg of carbimazole. Little is known about intrathyroidal concentrations of PTU. Eight hours after a single dose of 10 mg of MMI or 100 mg of PTU inhibition of intrathyroidal organification of iodide is about 90% and 60%,... 

Antithyroid drags have several side effects. The most frequent side effects are maculopapular rashes, pruritus, urticaria, fever, arthralgia and swelling of the joints. They occur in 1-5% of patients [1, 2]. Loss of scalp hair, gastrointestinal problems, elevations of bone isoenzyme of alkaline phosphatase and abnormalities of taste and smell are less common. The incidence of all these untoward reactions is similar with MMI and PTU. Side effects of MMI are dose-related, whereas those of PTU are less clearly related to dose [1]. PTU may cause slight transient increases of serum aminotransferase and y-glutamyl transpeptidase concentrations but also severe hq atotoxicity whereas methimazole or carbimazole can be associated with cholestasis. The side... 

Hyperthyroidism (thyrotoxicosis), defined as excessive thyroid activity, causes a state of thyroid hormone excess (thyrotoxicosis) characterized by an increased metabolic rate, increase in body temperature, sweating, tachycardia, tremor, nervousness, increased appetite and loss of weight. Common causes of hyperthyroidism are toxic multinodular goiter, toxic adenoma or diffuse toxic goitre ( Graves disease). Antithyroid diugs (methimazol, carbimazole, propylthiouracil) block thyroid hormone production and are hence suitable for the treatment of hyperthyroidism. 

BrN3 13973-87-0) see Cefoxitin bromoacetaldehyde diethyl acetal (C6H 3Bt02 2032-35-1) see Domiodol bromoacetaldehyde ethylene acetal (C4H7Br02 4360-63-8) see Carbimazole IV-bromoacetamide... 

C4H(,N2S 60-56-0) see Carbimazole (2-methyl-l-imidazolyl)acetone (C7H10N2O 31964-03-1) see Secnidazole p,P -(methylimino)bis(propiopheiioiie)... 

Carbimazole tends to cause neutropenia and patients are advised to report any sore throat to the pharmacist for referral. Blood counts would be required. Dry eyes are a consequence of hyperthyroidism and hypromellose eye drops could be recommended as a relief preparation. 

The patient should be advised to take cefuroxime tablets twice daily for 5 days. The patient should continue the carbimazole treatment. The patient should be advised to return to the pharmacist or to the physician if symptoms are aggravated during the cefuroxime treatment or if symptoms persist after the 5 days antibacterial treatment. 

Carbimazole is an antithyroid drug indicated in hyperthyroidism. It is usually administered as 15 mg daily in the morning. Carbimazole tends to cause agranulocytosis and therefore patients are advised to report immediately any signs of infections, such as sore throat. 

Caffeine, 111, 423, 424 Cannabis sativa, 394 Captodiamine, 44 Caramiphene, 90 Carbacephalothin, 420 Carbamazepine, 403, 404 Carbencillin, 414 Carbetapentane, 90 Carbethidine, 300 Carbimazole, 240 Carbinoxamine, 43 Carbonic anhydrase... 

Drugs used for hyperthyroidism can be classified as drugs that suppress thyroid hormone synthesis in the anterior lobe of the hypophysis, and they consist of diiodotyrosine and iodine, as well as drugs that suppress thyroid hormone synthesis in thyroid glands (propylthiouracil, methylthiouracil, methimazole, and carbimazole). 

The most useful drugs used for this purpose are classified as thioamides. They are chemically similar and contain thiourea-like thioamide functional groups. The most preferred are propylthiouracil and methimazole, although methylthiouracil and carbimazole are widely used. 

Indications for nsing carbimazole are the same as those of the aforementioned drugs. Synonyms of this drag are carbotiroid and neomercazole. 

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