Carbenicillin antimicrobial activity

The antimicrobial activity of carbenicillin, its indanyl ester (carbenicillin indanyl), and ticarcillin is extended to include Pseudomonas, Enterobacter, and Proteus spp. These agents are inferior to ampicillin against Gram-positive cocci and Listeria monocytogenes and are less active than piperacillin against Pseudomonas. 

The antimicrobial activity of cinnamon bark, lavender, marjoram, tea tree, peppermint EOs combined with ampicillin, piperacillin, cefazolin, cefuroxime, carbenicillin, ceftazidime, and merope-nem was investigated against p-lactamase-producing E. coll Fractional inhibitory concentration (FIC) values were the results of the trial. It was found that peppermint EO improved the activity of piperacillin against multidrug-resistant E. coli strains (FIC 0.31) compared with piperacillin alone. Also the used dose of meropenem can be reduced when combined with peppermint oil (FIC 0.26) (Xi Yap et ah, 2013). 

Carbenicillin has a broader range of antimicrobial activity than any other known penicillin. It is not absorbed orally and must be given by injection. Carbenicillin is synergistic with gentamicin colistin and streptomycin. ... 

---