Hypersensitivities carbamazepine

Oxcarbazepine Hyponatremia (serum sodium concentrations less than 125 mEq/L) has been reported and occurs more frequently during the first 3 months of therapy serum sodium concentrations should be monitored in patients receiving drugs that lower serum sodium concentrations (e.g., diuretics or drugs that cause inappropriate antidiuretic hormone secretion) or in patients with symptoms of hyponatremia (e.g., confusion, headache, lethargy, and malaise). Hypersensitivity reactions have occurred in approximately 25-30% of patients with a history of carbamazepine hypersensitivity and requires immediate discontinuation. 

Pirmohamed, M., et al., "TNFa Promoter Region Gene Polymorphisms in Carbamazepine-Hypersensitive Patients," Neurology, 56, 890-896 (2001). 

Pirmohamed, M. et al., TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients, Neurology., 56, 890, 2001. 

V. J. Green, M. Pirmohamed, N. R. Kitteringham, A. Gaedigk, D. M. Grant, M. Boxer, B. Burchell, B. K. Park, Genetic Analysis on Microsomal Epoxide Hydrolase in Patients with Carbamazepine Hypersensitivity , Biochem. Pharmacol. 1995, 50, 1353 -1359. 

Contraindications Co-administration of terfenadine, astemizole, cisapride, pimozide, or carbamazepine hypersensitivity to other phenylpiperazine antidepressants those who were withdrawn from nefazodone due to evidence of hepatic injury use within 14 days of MAOIs... 

Potentially fatal eosinophilic myocarditis may be a manifestation of carbamazepine hypersensitivity (SEDA-22, 86). 

The carbamazepine hypersensitivity syndrome has been reviewed (68). Some of the following cases are examples of the different manifestations of this syndrome. 

Elstner S, Sperling W. Das Carbamazepin-Hypersensitivitats-Syndrome. Differentialdiagnostische Erwagungen an einer exemplarischen FaUvorstellungo. [The carbamazepine hypersensitivity syndrome. Differential diagnosis and a representative case history.] Fortschr Neurol Psychiatr 2000 68(4) 188-92. 

Koga T, Kubota Y, Nakayama J. Interferon-gamma production in the peripheral lymphocytes of a patient with carbamazepine hypersensitivity syndrome. Acta Dermatol Venereol 2000 80(1) 73. 

Amstutz U, Ross CJ, Castro-Pastrana LI et al (2013) CPNDS Consortium. HLA-A 31 01 and HLA-B 15 02 are genetic markers for carbamazepine hypersensitivity in children. Clin Pharmacol Ther 94 142-149... 

Pirmohamed, M., A. Graham, P. Roberts, D. Smith, D. Chadwick, A.M. Breckenridge et al. (1991). Carbamazepine-hypersensitivity Assessment of clinieal and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine. Br. J. Clin. Pharmacol. 32, 741-749. 

Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, Smith JC, March RE, Chadwick DW, Park BK, Pirmohamed M (2005) Association between serious carbamazepine hypersensitivity reactions and the HSP70 gene cluster. Toxicology 213 264—265 Alfirevic A, Jorgensen AL, Williamson PR, Chadwick DW, Park BK, Pirmohamed M (2006) HLA-B locus in Caucasian patients with carbamazepine hypersensitivity. Pharmacogentnnics 7 813-818... 

Pirmohamed M, Graham A, Roberts P, Smith D, Chadwick D, Breckenridge AM, Park BK (1991) Carbamazepine hypersensitivity assessment of clinical and in vitro chemical cross-reactivity with phenytoin and oxcarbazepine. Br J Clin Pharmacol 32 741-749 Pirmohamed M, Breckenridge AM, Kitteiingham NR, Park BK (1998) Fortnightly review -adverse drug reactions. BMJ 316 1295-1298... 

Musculoskeletal In a young patient a tendon sheath abscess was considered a possible complication of severe carbamazepine hypersensitivity [96 ]. 

Khatami A, Singh-Grewal D, Kilham H. Tendon sheath abscess and severe carbamazepine hypersensitivity. J Paediatr Child Health 2008 44(7-8) 462-3. 

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