Carbamate anticonvulsants

First, mobile phase and column we saw that most of the small molecule separations could be made on a C18 column in An/buffer water, with the exception of charged molecules and carbohydrates, which are too water soluble. We saw a range of polarity from fat-soluble vitamins, steroids, triglycerides, chlorinated pesticides eluting in 60-80% An/water, to carbamate, phosphate pesticides, anticonvulsants, antidepressants at 40-50% An/water, to nucleosides, nucleotides, aspirin, and water-soluble vitamins at 5-10% An/water. If you know something about the compound s structure or its solubility, you have a good clue as to what mobile phase can be used for its separation. 

Therapeutic Function Anticonvulsant, Tranquilizer Chemical Name (Phenylmethyl)carbamic acid 2-hydroxyethyl ester Common Name Buramate Hyamate Structural Formula ... 

Sellstrdm, A. (1992). Anticonvulsants in anticholinesterase poisoning. In Clinical and Experimental Toxicology of Organophosphates and Carbamates (B. Ballantyne, T.C. Marrs, eds), pp. 578-86. Butterworth-Heinemann, Oxford. 

Felbamate. Felbamate is an adjuvant anticonvulsant, containing the warning that its use is associated with a marked increase in the incidence of aplastic anemia and that patients being started on the drug should have liver function tests performed before therapy is initiated. Animal studies have revealed a statistically significant increase in hepatic cell adenomas in high dose studies (18). It is postulated that this cancer was induced by toxic by-products urethane and methyl carbamate. Felbamate is not recommended as first-line therapy and is indicated for those patients who respond inadequately to alternative treatments and whose epilepsy is so severe that a substantial risk of aplastic anemia or liver failure is deemed acceptable in light of the benefits provided by its use. 

Berger, F. M. The anticonvulsant activity of carbamate esters of certain 2,2-disubstituted-l,3-propanediols. J. Pharmacol. Exp. Ther. 1952,104, 229-233. 

Felbamate [25451-15-4], anticonvulsant, 109. 2-Phenyl-l,3-propanediol dicarbamate 109 (Felbamate) is prepared from 2-phenyl-l,3-propanediol 106 with phosgene [83], ethyl carbamate 107 [84, 85], or chlorosulfonyl isocyanate 108 [84, 85]. 

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