Capsular molecular size

Figure 4.17 Reduced diffusion coefficient as a function of molecular size. Hydrodynamic radii were determined from the diffusion coefficient in water according to Equation 4-4. (a) Diffusion of proteins and peptides in mid-cycle human cervical mucus [5], Measurements were performed by FPR (squares) or quantitative imaging of fluorescence profiles (circles), (b) Protein and dextran diffusion through granulation (squares) or tumor tissue (circles) in the rabbit ear [20, 21]. (c) Glucose diffusion through capsular tissue (squares) and cartilage (circles and triangles) [92]. Each symbol represents a separate measurement.

Bureau of Biologies. Molecular sizing of capsular polysaccharide antigens by Sepharose 4B column chromatography. BOB SOP pp 15. Food and Drug Administration, 1977. 

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