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Capsaicin biological actions

The biological actions of capsaicin are primarily attributable to release of the neuropeptide substance P, calcitonin gene-related peptide (CGRP), and neurokinin A from sensory neurons. These transmitters from primary sensory neurons communicate witir other cell types. They produce alterations in the airway mucosa and neurogenic inflammation of the respiratory epithelium, airway blood vessels, glands, and smooth muscle. Alterations in multiple effector organs lead to bronchoconstriction, increased vascular permeability, edema of the tracheobronchial mucosa, elevated mucosal secretion, and neutrophil chemotaxis (Tominack and Spyker, 1987). Capsaicin-induced effects of bronchoconstriction, vasodilation, and plasma protein extravasation are mediated by substance P. In addition, substance P can cause bronchoconstriction through stimulation of c-fibers in pulmonary and bronchial circulation. [Pg.138]

Geppetti P, Del Bianco E, Patacchini R, et al. (1991) Low pH-induced release of calcitonin gene-related peptide from capsaicin-sensitive sensory nerves mechanism of action and biological response. Neuroscience 41 295-301... [Pg.59]


See other pages where Capsaicin biological actions is mentioned: [Pg.160]    [Pg.105]    [Pg.438]    [Pg.264]    [Pg.186]    [Pg.4503]    [Pg.4534]    [Pg.95]    [Pg.97]    [Pg.115]   
See also in sourсe #XX -- [ Pg.160 ]




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