Capsaicin biochemical mechanisms

Dray, A. Neuropharmacological mechanisms of capsaicin and related substances, Biochem. Pharmacol. 1992, 44, 611-615. 

Purkiss, J., Welch, M., Doward, S. and Foster, K. (2000) Capsaicin stimulated release of substance P from cultured dorsal root ganglion neurons involvement of two distinct mechanisms. Biochemical Pharmacology 59(11), 1403-1406. 

The mechanism of this interaction is not understood. It has been proposed that tacrolimus may act on the same biochemical pathway as alcohol potentiating a capsaicin-mediated release of neuropeptides, which increase vasodilatory effects. Alternatively, cutaneous aldehyde dehydrogenase inhibition in areas where tacrolimus has been applied may increase cutaneous aldehyde levels that, through prostaglandins as mediators, could lead to vasodilation following alcohol consumption. - ... 

Kurita, S., Kitagawa, E., Kim, C., Momose, Y, and Iwahashi, H. 2002. Studies on the antimicrobial mechanism of capsaicin using yeast DNA microarray. Biosci. Biotechnol. Biochem. 66 532—536. 

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