Capillary electrophoresis chemometric methods

Chemometric Methods in Capillary Electrophoresis. Frank A. Gomez... 

APPLICATION OF CHEMOMETRIC METHODS IN DRUG PURITY DETERMINATION BY CAPILLARY ELECTROPHORESIS... 

CHEMOMETRIC METHODS APPLIED TO GENETIC ANALYSES BY CAPILLARY ELECTROPHORESIS AND ELECTROPHORESIS MICROCHIP TECHNOLOGIES... 

In this chapter we summarize the complex issues that are involved in the analysis of sizing DNA by capillary electrophoresis (CE), and how chemomet-ric methods can help to optimize a high number of interrelated variables. It is impressive to observe how diverse is the obtainable biological information despite the size of the double-stranded DNA molecule. We also briefly introduce some typical genetic assays that rely on sizing DNA molecules, and how some chemometric approaches are used to correlate sizes of DNA with population and or evolution of species. 

Chemometric methods in capillary electrophoresis / edited by Grady Hanrahan,... 

The goal of this book is to present modern chemometric methods utilized in capillary electrophoresis (CE) to help alleviate the problems commonly encountered during routine analysis and method development. Its scope is to focus on current chemometric methods utilized in CE endeavors—techniques developed and routinely incorporated by research-active experts in the field. 

Subsequent chapters cover the major disciplines of separation sciences and spectroscopy. Recognising the importance and breadth of the area of separation sciences, our authors concentrate on method development in high performance liquid chromatography (HPLC or LC), capillary electrophoresis (CE), gas chromatography (GC) and thin layer chromatography (TLC), discussing traditional approaches in addition to the newer computational and chemometric methods. 

To date, the use of chemometrics for method development and robustness testing has been published for all areas of CE, including capillary zone electrophoresis (CZE), capillary electrokinetic chromatography (EKC) using chiral selectors for enantioseparations, micellar electrokinetic chromatography (MEKC), and microemulsion electrokinetic chromatography (MEEKC). A comprehensive description can be found in Chapters 5 and 13 as well as in recent reviews (6-11). Several monographs on chemometrics in analytical chemistry have been published such as References 12-14. This chapter will... 

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