Capillary Cascade development

In the process of cancer metastasis, tumor cells have to migrate from their primary location to distant sites. Consequently, those cells endowed with higher motility and invasive abilities, and that can resist the shear stress of being transported through narrow capillaries, will have higher chances to complete the metastatic cascade, and develop into metastatic colonies. Hence, selection in vitro for cells in which any of those characteristics is expressed at the highest level could result in some increase of the metastatic ability. 

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